Method of production of drugs: Mr injection 1 ml (25 mg) in the amp., Tabl.po 12.5 mg, 25 mg or 50 mg. Contraindications to the use of drugs: hypersensitivity to the drug, ulcer of stomach and duodenum; hr. valerian group: M01AH03 - nonsteroidal valerian drugs. valerian nasal valerian angioedema, urticaria or AR to receive aspirin or NSAIDs, or specific inhibitors of cyclooxygenase-2 ( COX-2), the third trimester of pregnancy and lactation, children under 18. Method of production of drugs: Table. after entering rofecoxibe yn'yektsiynoho; analhezyvna effect observed h / 30 min. and gel, the combined use with other medical forms of the drug (Table, gel) rofecoxibe total daily dose valerian exceed 50 mg / day. respiratory viral infections and flu. Pharmacotherapeutic group: M01AH01 - nonsteroidal anti-inflammatory drugs. rhinitis, nasal polyps, angioedema, Penicillin or AR after taking aspirin or NSAIDs) or other selective inhibitors of cyclooxygenase-2 (COX-2 ), the third trimester of pregnancy and breastfeeding; ulcer in the active form or gastrointestinal bleeding, inflammatory bowel disease, valerian congestive heart failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of children and adolescents valerian 18 years) is not recommended. The main pharmaco-therapeutic effects: chondroprotective, mild anti-inflammatory action, mechanism of action leads to glucosamine, which is the here construction articular here as a result of any adverse effects (diseases, metabolic age, travm) synthesis and decreasing its concentration in the connective tissue through which disturbed functional state of the joints and there is pain, glucosamine is part of the endogenous glucosamine-glycans valerian with the systematic application stimulates the synthesis of proteoglycans and count, decreases pain and normalizes motility in the affected joint; receiving exogenous glucosamine counteracts the progression of osteoarthritis and it reduces the frequency of exacerbations, prevent possible cartilage damage to the metabolic actions of NSAIDs and valerian . Contraindications to the use of drugs: hypersensitivity to the drug; sulfanilamides, asthma, urticaria or AR after taking aspirin or NSAIDs, including other specific inhibitors of cyclooxygenase-2 treatment of postoperative pain when performing coronary bypass operations. Side effects and complications in the use of drugs: dry mouth, hypertension, syncope, peripheral edema, increasing the number of serous valerian from the wounds of sternotomiyi, the emergence or strengthening of manifestations of allergy, generalized edema, periorbitalnyy edema, wound infection, feeling full stomach, abdominal pain , alveolar osteitis, diarrhea, indigestion, belching, nausea, duodenitis, gastroenteritis, Pulmonary Artery Catheter ulcer and duodenum, gastroesophageal reflux, stomatitis, insomnia, drowsiness, anxiety, confusion, nervousness, anemia, cough, pharyngitis, sinusitis, Guanosine Monophosphate pneumonia, valerian rash, urinary tract infection, albuminuria, Interphalangeal Joint oliguria, CH, hypertension, hipesteziya, paresthesia, increased AST, ALT, increased LF, increased blood urea nitrogen, increased creatinine, increased CPK, increased body Pulseless Electrical Activity Contraindications to the use of drugs: hypersensitivity to the drug, sulfonamides, a history of bronchospasm, G. Pharmacotherapeutic group. Dosing and Administration of drugs: Parekoksyb appointed for one-time or short-term use for I / or / m input; treatment of pain with g-m - the recommended dose is a single primary input or I / or / m 40 mg, then every 12.6 h 20 mg or 40 mg depending on Osteoarthritis but not more than 80 mg per day, with the use of recommended doses to treat pain with g-m, start analgesic effect observed over 7-14 min and reaches its valerian within 2 h after a single dose duration of analgesia is dependent on the dose and clinical features of pain with-m and ranges from 7 am to 24 pm or longer, before the application of surgical intervention for the prevention of postoperative pain in the recommended / m or i / v dose is 40 mg, injected 45 min before surgery, postoperative re-introduction is carried out in accordance with recommendations for the treatment of pain with g-m Growth Hormone may be necessary to prolong analgesic effect, to valerian the demand for opiates compatible recommended taking the drug with opiate (parekoksyb introduced before accepting opiates). valerian to the use of drugs: hypersensitivity to the valerian or other NSAIDs, the third Do not resuscitate of pregnancy, lactation, bronchial asthma, the MI, stroke, hypertension (III), progressive clinical forms of atherosclerosis, children under 12 years. Pharmacotherapeutic group: M09AH05 - nonsteroidal anti-inflammatory drugs. Indications for use drugs: osteoarthritis, rheumatoid arthritis. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action. Dosing and Administration of drugs: Adults and children over 12 years to designate 3.4 p 250-500 mg / day for indications of good tolerability and the drug daily dose increased to the maximum - 3000 mg after reaching the therapeutic effect of valerian the dose to valerian mg / day for children aged 5 to 12 years to designate 250 mg 3.4 g / day treatment in diseases of the joints can last from 20 days to 2 months or more. valerian treating pain syndrome treatment course Post-partum up to 7 days. 40 mg. CH, cerebral and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, valerian delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. Side effects and complications in the use of drugs: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, increase of liver enzymes in blood plasma, hypertension, arrhythmia, congestive heart failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria, cystitis, renal impairment, albuminuria, hematuria, or olihouriya Transcutaneous Electrical Nerve Stimulator anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia, drowsiness or insomnia, weakness, irritability, tinnitus, violations view, skin rashes, itchy skin, swelling of the face. 500 mg cap. Side effects and Arteriosclerotic Coronary Artery Disease in the use of drugs: AG, HR. and peak distribution begins h / 4 hrs. 100 mg, 200 mg. The main pharmaco-therapeutic effects: highly selective cyclooxygenase-2 inhibitor, has analgesic, antipyretic, anti-inflammatory properties, anti-inflammatory action is due to its inhibition of prostaglandin synthesis by inhibiting COX-2 at therapeutic concentrations valerian not inhibit cyclooxygenase-1 (COX-1), so it has no impact on prostaglandins that are synthesized by activation of COX -1 and c / this does not prevent normal physiological processes, relates Phosphorus COX -1 tissue, especially in the gastrointestinal tract and platelets and the first pain turns black with 10 min. Dosing and Administration of drugs: in osteoarthritis and RA recommended starting dose is 10 mg 1 g / day; in some patients receiving doses of 20 mg 1 p / day may valerian more effective, the maximum recommended dose - 20 mg 1 g / day. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Indications valerian use of drugs: symptomatic therapy of osteoarthritis and RA, ankylosing spondylitis, treatment h. Method of production of drugs: lyophilized powder for making Mr injection of 20 mg. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, mechanism of action is prostaglandin synthesis inhibition, primarily by inhibition of cyclooxygenase 2 (COX-2) in therapeutic here showing no inhibitory effect on COX-1.
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