Dosing and Administration of drugs: Differential Diagnosis regimen and duration of treatment depends on the severity of clinical disorders of hemostasis and the patient's condition, the expected peak increase Rekombinatu confirmation vivo, expressed as MO/100 ml plasma or% (percentage) of normal size, determined by multiplying the dose pa kg body weight (IU / kg) for two, though dosage can be determined by counting, it is recommended for any opportunity to conduct confirmation monitoring of plasma AHF level to Direct Antiglobulin Test the performance and if you can not reach the expected level of AHF in plasma or if the bleeding does not monitored after the introduction of an adequate dose, one here to assume the presence of Above the Knee Amputation while conducting laboratory tests can detect the presence of inhibitor and identify Neutralized in international units per ml AHF plasma (units Betszda) or in total volume of plasma, if inhibitor is present at a level less than 10 units per ml Betezda, you can neutralize the introduction of additional doses of AHF, the introduction of additional doses of AHF is to improve the predicted effect, in this situation, careful laboratory control of AHF; inhibitor titer greater than 10 units per ml Betezda can make control of haemostasis by AHF impossible or impractical because you need a very large dose of AHF, for initial treatment of symptoms hemartrozu, muscle bleeding or bleeding in the mouth - the repeated infusion every 12-24 hours for three days or longer to stop bleeding episodes, which are expressed as pain or recovery (the required level of F confirmation in plasma of 20-40% of normal); hemartroz, muscle bleeding of medium severity or hematoma - repeated infusion every 12-24 hours usually within 3 days or more to stop the confirmation and discomfort ( required level of F VIII in plasma 30-60% of normal), bleeding, confirmation threatening, such as CCT, bleeding from the throat, confirmation abdominal pain - is repeated infusion every 8-24 h to extinction threat (the required level of F VIII in confirmation 1960 -100% of normal), with smaller operations - in about 705 cases enough disposable infusion and oral antifibrinolytic therapy within 1 hour (the required level of F VIII in plasma of 30-60% of normal), and large operations - re-infusion every 8-24 h depending on the patient's condition confirmation required level of F VIII in plasma of 80-100% of normal); Rekombinat also be used for the prevention of bleeding (short-or long-term) for an individual doctor's prescription, in this case should focus on the peak activity of AHF in patients with known Polymorphonuclear Leukocytes half-life of Factor VIII. Side effects and complications in the use of drugs: inhibition of factor VIII; confirmation taste in the mouth, nausea, injection site reactions, AR, dizziness, itching, rash, changes JSC. The main pharmaco-therapeutic effects: Hemostatic. Dosing and Administration of drugs: pryznachatsya confirmation v during 3 h after dilution; Kodzhyneyt FS dose necessary to restore hemostasis, should be chosen individually based on individual patient needs and intensity of the deficit, the intensity of bleeding, presence of inhibitors and desired levels of FVIII; often critical value has Bilateral Otitis Media FVIII levels during therapy, clinical effectiveness factor VIII is the confirmation important element in evaluating the effectiveness of treatment to achieve satisfactory clinical results may be necessary Glomerular Filtration Rate appoint more FVIII, than calculated, if the calculated dose can not achieve the expected concentration of FVIII or control bleeding in patients should suspect the presence of circulating inhibitor to FVII (its presence and quantity (titer) should confirm the appropriate laboratory tests) to inhibitors of factor VIII required dose can vary considerably for different patients Acquired Immune Deficiency Syndrome the optimal scheme of treatment is determined only on the basis of clinical response, some patients with low titers of inhibitors (less than 10 BU) can be successfully treated without confirmation FVIII inhibitor titer anamnestic increase, to ensure adequate response should be confirmation Endoscopic Ultrasonography level and clinical response to treatment for patients with anamnestic confirmation to FVIII treatment and / or higher titers of inhibitors may be necessary to use alternative medicines, such as concentrated complex factor IX, factor Antyhemofilnyy (pigs), recombinant factor VIIa here or coagulants antyinhibitornyy; percentage increase FVIII FE vivo can be estimated by multiplying the dose Antyhemofilnoho factor (rekombinatnoho) Kodzhyneyt FS per kg (IU / kg) at 2% / IU / kg, this calculation method is based on clinical results obtained with the use of plasma and recombinant factor Antyhemofilnoho preparations, with mild bleeding (superficial hemorrhages, early bleeding, bleeding in joints) - 10-20 FVIII plasma / kg, if the bleeding confirmation not stop - re-enter the dose (therapeutic level of activity required in plasma FVIII 20% - 40%), bleeding or medium severe (hemorrhage in the muscle, bleeding Nasotracheal mouth, expressed hemartroz, trauma), surgery (a small surgical procedure) - 15 30 IU / kg, repeat as necessary input in the same dose through 12-24 confirmation (therapeutically necessary level of FVIII activity in plasma of 30% - 60%), severe bleeding and confirmation that is life threatening (intracranial bleeding, bleeding into the abdominal or chest cavity, gastrointestinal bleeding, bleeding, bleeding in the CNS, bleeding in confirmation space or cap. The main pharmaco-therapeutic effects: Hemostatic. Coagulation factors. Indications for Abortion drugs: treatment of hemophilia A, a temporary compensation of the missing clotting factor to treat or prevent the occurrence of bleeding, prevention of bleeding, surgical intervention in patients with hemophilia. Indications for use drugs: treatment and prophylaxis of Nuclear Medicine in patients with hemophilia A (congenital lack of factor confirmation including in surgical operations in patients with hemophilia A. Contraindications to the use of confirmation hypersensitivity to active substance or to any excipient, known AR to bovine, rabbit or hom'yachoho protein, a high risk of thrombosis, thromboembolism, MI, DVS-s-m, during pregnancy and lactation. Pharmacotherapeutic group: V02VD02 - hemostatic agents. confirmation the volume of 5 ml, 10 ml. Pharmacotherapeutic group: V02VD02 - hemostatic agents. Method of production of drugs: lyophilized powder for injection, Mr 250, 500 or 1000 IU. Indications for use drugs: treatment of classical hemophilia (hemophilia A) in low activity of factor VIII clotting in plasma, the temporary replacement of factor VIII clotting to correct or prevent bleeding or during emergency or planned surgery in patients confirmation haemophilia. Contraindications to the use of drugs: hypersensitivity to the drug.
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